Varicella-zoster virus infection in children with underlying human immunodeficiency virus infection |
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Authors: | AA Gershon N Mervish P LaRussa S Steinberg SH Lo D Hodes S Fikrig V Bonagura S Bakshi |
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Affiliation: | Department of Pediatrics, Columbia University College of Physicians & Surgeons, and Mt. Sinai Medical Center, New York, New York 10032, USA. |
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Abstract: | This article describes a prospective longitudinal study of varicella-zoster virus (VZV) infections in human immunodeficiency virus (HIV)-infected children, designed to determine their natural history of VZV infection and possible effects of VZV on the progression of HIV infection. Varicella was usually not a serious acute problem, and it did not seem to precede clinical deterioration. The rate of zoster was high: 70% in children with low levels of CD4+ lymphocytes at the time of development of varicella. It is predicted that immunization with live attenuated varicella vaccine is unlikely to be deleterious to HIV-infected children. Moreover, if they are immunized when they still have relatively normal levels of CD4+ lymphocytes, they may have a lower rate of reactivation of VZV than if they were allowed to develop natural varicella when their CD4+ cell counts have fallen to low levels as a result of progressive HIV infection. |
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