m-Chlorophenylpiperazine (mCPP) Modulates the Discriminative Stimulus Effects of Cocaine Through Actions at the 5-HT?C Receptor.

Agonists acting at the serotonin-1B receptor (5-HT?BR) and 5-HT?CR have been reported to potentiate and block, respectively, the discriminative stimulus effects of cocaine. The present investigation reassessed the antagonistic effects of the mixed 5-HT?C/?BR agonist m-chlorophenylpiperazine (mCPP) on the discriminative stimulus effects of cocaine in the presence or absence of selective antagonism of the 5-HT?BR or 5-HT?CR. The stimulus effects of cocaine were attenuated by mCPP at doses that reduced response rates. The selective 5-HT?CR antagonist SB 242084, but not the selective 5-HT?BR antagonist GR 127935, reversed the mCPP-evoked attenuation of the cocaine cue and the suppression of response rates. These results demonstrate that the suppressive effects of mCPP on cocaine discrimination are related to stimulation of the HT?CR. (PsycINFO Database Record (c) 2010 APA, all rights reserved)