| 曲匹地尔合成工艺的研究 |
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| 引用本文： | 付金广. 曲匹地尔合成工艺的研究[J]. 山东化工, 2014, 0(8): 15-16 |
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| 作者姓名： | 付金广 |
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| 作者单位： | 山东方明药业集团股份有限公司,山东菏泽274500 |
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| 摘 要： | 以氨基碳酸胍和甲酸为原料加入环合剂POCl3和缩合剂DCC-HOBT,使反应时间缩短了,生成的中间体5-甲基-7羟基-1,2,4-三氮唑[1,5-a]嘧啶收率高,重结晶用新型复合溶剂在产率、质量与文献[1-2]相比有较大提高与改善,收率由61%[1-2]提高到75%。
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| 关 键 词： | 工艺合成 环合剂 缩合剂 复合溶剂 |
Study on the Synthesis of Trapidil |
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| Fu Jinguang. Study on the Synthesis of Trapidil[J]. Shandong Chemical Industry, 2014, 0(8): 15-16 |
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| Authors: | Fu Jinguang |
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| Affiliation: | Fu Jinguang ( Shandong Fangming Pharmaceutical Group Co. ,Ltd. , Heze 274500 ,China) |
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| Abstract: | Using anino guanidine carbonate and formic acid as raw material to join the cyclizing agent POCl3 and condensation agent DCC - HOBT, the reaction time shortened, methyl intermediates generated 5 - methyl - 7 hydmxy - 1, 2,4- three triazole [ 1,5 - a ] pyrimidine high yield, reerystallization model compound solvent on yield, quality and operation time and the literature compared with improved greatly and improve yield by 61% to 75%. |
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| Keywords: | synthesis ring mixture condensing agent mixed solvent |
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