| Darzens反应合成甲基己基乙醛 |
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| 引用本文： | 陈文抗. Darzens反应合成甲基己基乙醛[J]. 山东化工, 2014, 0(9): 22-24 |
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| 作者姓名： | 陈文抗 |
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| 作者单位： | 淮安万邦香料工业有限公司,江苏淮安223300 |
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| 摘 要： | 溶剂法缩合制甲基己基乙醛,以甲基壬酮与α-卤代酸酯在无水碱催化下,通过Darzens反应生成α,β-环氧酸酯,经皂化、酸化、加热脱羧而得,并对该工艺进行优化,缩合反应以石油醚为溶剂,反应温度为10~15℃,缩合收率达到75%;水解反应:用25%的NaOH溶液;脱羧反应:用2%的硫酸,使甲基己基乙醛总收率达到61%。
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| 关 键 词： | Darzens反应 甲基己基酮 甲醇钠 氯乙酸甲酯 |
Symthesis of Methyl Hexyl Acetaldehyde by Darzems Reactiom |
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| Chen Wenkang. Symthesis of Methyl Hexyl Acetaldehyde by Darzems Reactiom[J]. Shandong Chemical Industry, 2014, 0(9): 22-24 |
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| Authors: | Chen Wenkang |
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| Affiliation: | Chen Wenkang (Huaihn Wanbang Aromatic Chemicals Industry Co. , Ltd. , Huai＇an 223300, China) |
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| Abstract: | The solvent method for synthesizing methyl hexyl acetaldehyde,under the anhydrous and alkali catalysis,methyl nonyl ketone and α - halogenated acid ester via Darzens reaction to generate α,β - epoxy acid ester,saponification, acidification,heating and decarboxylation. The optimum process conditions acquired：petroleum ether as solvent,reaction temperature for 10 - 15℃ for condensation,condensation rate of reached 75% ;25% NaOH solution for saponification;2% sulfuric acidhyl sulfoxide for decarboxylation,the methyl hexyl acetaldehyde must rate reached 61% . |
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| Keywords: | Darzens reaction methyl ethyl ketone sodium methoxide and methyl chloroacetate |
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