Enriched separation of protopanaxatriol ginsenosides,malonyl ginsenosides and protopanaxadiol ginsenosides from Panax ginseng using macroporous resins |
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| Authors: | Jianing Mi Min Zhang Guixiang Ren Hongyang Zhang Yuerong Wang Ping Hu |
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| Affiliation: | 1. Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China;2. Modern Engineering Center for Traditional Chinese Medicine, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | This study developed a method for enriched separation of protopanaxatriol ginsenosides, malonyl ginsenosides and protopanaxadiol ginsenosides from Panax ginseng. The method began with targets extraction from herbal material, followed by HPD300 resins separation, then extracted by water-statured n-butanol. In the product achieved, protopanaxatriol ginsenosides were 24.4% pure with 70.9% recovery, malonyl ginsenosides were 33.4% pure with 23.3% recovery, and protopanaxadiol ginsenosides as well as Ro were 31.3% pure with 56.8% recovery. The adsorption test data on HPD300 resins fit the Langmuir model well. Moreover, the pseudo-first-order kinetic model showed the best correlation with the adsorption results. These findings indicate that the combination of HPD300 resin chromatography and water-statured n-butanol extraction effectively separates and enriches ginsenosides from P. ginseng. |
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| Keywords: | Enriched separation Ginsenosides Malonyl ginsenosides Macroporous resin |
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