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Assessment of Bonelike® graft with a resorbable matrix using an animal model |
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| Authors: | J.V. Lobato,N. Sooraj Hussain,C.M. Botelho,A.C. Maurí cio,A. Afonso,J.D. Santos |
| Affiliation: | a CHVNG-Serviço de Estomatologia, Centro Hospitalar de Vila Nova de Gaia, Portugal b ICBAS-Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Largo Professor Abel Salazar, 2, 4099-003 Porto, Portugal c CECA/ICETA-Centro de Estudos de Ciência Animal, Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Campus Agrário de Vairão, Rua Padre Armando Quintas, 4485-661 Vairão, Portugal d INEB-Instituto de Engenharia Biomédica, Laboratório de Biomateriais, Rua Campo Alegre, 823, 4150-180, Porto, Portugal e FEUP-Faculdade de Engenharia da Universidade do Porto, DEMM, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal f FMDUP-Faculdade de Medicina Dentária da Universidade do Porto, Rua Dr. Manuel Pereira da Silva, 4200-393 Porto, Portugal g Department of Mechanical Engineering, University of Aveiro, 3810-193 Aveiro, Portugal |
| Abstract: | Synthetic bone grafts have been developed to provide an alternative to autografts and allografts. Bonelike® is a patented synthetic osteoconductive bone graft that mimics the mineral composition of natural bone. In the present preliminary animal studies a user-friendly version of synthetic bone graft Bonelike® have been developed by using a resorbable matrix, Floseal®, as a vehicle and raloxifene hydrochloride as a therapeutic molecule, that is known to decrease osteoclast activity and therefore enhanced bone formation. From histological and scanning electron microscopy evaluations, the use of Bonelike® associated with Floseal® and raloxifene hydrochloride showed that new bone was rapidly apposed on implanted granules and also that the presence of the matrix and therapeutic molecule does not alter the proven highly osteoconductivity properties of Bonelike®. Therefore, this association may be one step-forward for the clinical applications of Bonelike® scaffolds since it is much more easy-to-handle when compared to granular materials. |
| Keywords: | Bonelike® FloSeal® Raloxifene hydrochloride Animal model Histological analysis |
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