2018—2019年浙江省养殖水产品中6种喹诺酮类药物残留分析及风险评估

目的 评估2018—2019年浙江省养殖水产品中6种喹诺酮类药物残留分析及风险.方法 2018—2019年随机抽检浙江省11个地市658家养殖场的养殖水产品,采用液相色谱-串联质谱法对水产品中恩诺沙星、环丙沙星、氧氟沙星、诺氟沙星、培氟沙星、洛美沙星6种喹诺酮类药物残留进行分析,同位素内标法定量计算得到喹诺酮类药物残留...

Analysis and risk assessment of 6 quinolones residues in aquatic products in Zhejiang province from 2018 to 2019

Objective To evaluate the analysis and risk of six quinolones residues in aquaculture products in Zhejiang province from 2018 to 2019.Methods Aquatic products in 658 aquafarms of 11 region in Zhejiang province were sampled from 2018 to 2019,and enrofloxacin,ciprofloxacin,ofloxacin,norfloxacin,pefloxacin and lomefloxacin were detected.Liquid chromatography-tandem mass spectrometry was used for detection,and the residual range of quinolones was calculated by isotopic internal standard method.The actual daily intake range was obtained by comparing the literature with the maximum allowable daily intake.Results The detection rates of 6 quinolones in aquatic products were 0?24.2%,and the residue were 0?964μg/kg.The residue of fish samples was highest up to 964μg/kg,and the kinds of residues detected in turtle samples were the most up to 4,the highest exceeding standard rate was 18.2%in frog samples.The detection rate of the 6 quinolones in aquafarms in Huzhou was the highest up to 29.6%.Taking 75 g of aquatic products per person per day as an example,the intake of enrofloxacin ranged from 0.58μg to 115.73μg,accounting for 0.16%to 31.11%of the maximum allowable daily intake.Conclusion A certain amount of quinolones is detected in aquaculture aquatic products in Zhejiang province,mainly limited to enrofloxacin and ciprofloxacin,with low health risk and relatively safe level.The detection rates of ofloxacin,norfloxacin,pefloxacin and lomefloxacin are low,but the residual contents in individual samples are high,and the maximum allowable daily intake are not clear,which have potential hazards.