| 8-氨基苯并[4,5]呋喃并[3,2-d]嘧啶类衍生物的合成与结构表征 |
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| 引用本文： | 马明霞.8-氨基苯并[4,5]呋喃并[3,2-d]嘧啶类衍生物的合成与结构表征[J].精细化工,2013,30(4):456-460. |
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| 作者姓名： | 马明霞 |
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| 作者单位： | 贵州大学精细化工研究开发中心,贵州贵阳,550025 |
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| 基金项目： | 贵州大学研究生创新基金项目(NO. 2012031) |
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| 摘 要： | 以5-硝基水杨醛为原料,经过氰基化、醚化、两次成环、氯代等反应合成11个新型的8-位氨基取代苯并4,5]呋喃并3,2-d]嘧啶类化合物,利用1HNMR、13CNMR、IR和MS对其结构进行了表征,并对该反应条件进行了探索,得出最优的反应条件。
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| 关 键 词： | 5-硝基水杨醛 8-氨基苯并[4 5]呋喃并[3 2-d]嘧啶 结构表征 医药原料 |
| 收稿时间： | 2013/1/14 0:00:00 |
| 修稿时间： | 2013/2/27 0:00:00 |
Synthesis and structural characterization of 8-aminobenzo[4,5]furo[3,2-d]pyrimidine Derivatives |
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| MA Ming-xia.Synthesis and structural characterization of 8-aminobenzo[4,5]furo[3,2-d]pyrimidine Derivatives[J].Fine Chemicals,2013,30(4):456-460. |
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| Authors: | MA Ming-xia |
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| Affiliation: | (Research and Development Center of Fine Chemicals,Guizhou University,Guiyang 550025,Guizhou,China) |
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| Abstract: | Using 2-hydroxy-5-nitrobenzaldehyde as starting compound, ten novel 8-aminobenzo4,5]furo 3, 2-d]pyrimidine derivatives were synthesized through cyanation, esterification, cyclization and chlorization. Title compounds were fully characterized by 1H NMR, 13C NMR, IR, and MS. In addition, the reaction conditions were explored, and got optimized condition. |
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| Keywords: | 5-nitrosalicylaldehyde 8-Nitrobenzo[4 5]furo[3 2-d]pyrimidine synthesis structural characterization |
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