| 基于邻二氮菲-Fe2+的间接显色光度法检测片剂中的卡托普利 |
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| 引用本文： | 董娜,杨斌全,王少勇,张小林.基于邻二氮菲-Fe2+的间接显色光度法检测片剂中的卡托普利[J].化学世界,2021(1):23-27. |
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| 作者姓名： | 董娜 杨斌全 王少勇 张小林 |
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| 作者单位： | ;1.甘肃医学院药学系 |
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| 基金项目： | 甘肃省高等学校创新能力提升(Nos.2019A-159,2020A-163);2019甘肃省高等学校教育教学成果培育资助项目。 |
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| 摘 要： | 卡托普利还原Fe3+,Fe2+与邻二氮杂菲显色物在510 nm处有最大吸收,吸光度(A)与卡托普利浓度有相关性。结果表明,卡托普利浓度(c)在1×10-6~1×10-4 mol/L范围内与A呈良好的线性关系:y=0.006 4c+0.005 5,相关系数(r)=0.997 6,检测限为9.37×10-7 mol/L。该方法用于片剂卡托普利测定,结果满意。
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| 关 键 词： | 卡托普利 邻二氮菲 显色光度法 |
Determination of Captopril in Tablets with Indirect Colorimetric Method Based on o-Phenanthroline-Fe~(2+) |
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| Dong Na,Yang Binquan,Wang Shaoyong,Zhang Xiaolin.Determination of Captopril in Tablets with Indirect Colorimetric Method Based on o-Phenanthroline-Fe~(2+)[J].Chemical World,2021(1):23-27. |
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| Authors: | Dong Na Yang Binquan Wang Shaoyong Zhang Xiaolin |
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| Affiliation: | (Department of Pharmacy,Gansu Medical College Pingliang,Gansu 744000,China) |
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| Abstract: | Fe3+ was reduced to Fe2+ by captopril and the maximal absorption wavelength of o-phenanthroline-Fe2+ was 510 nm so that the absorbance was well related with the concentration of captopril. The results showed that within the range of 1×10-6~1×10-4 mol/L,the absorbance was in a good linear relationship with the concentration of captopril. The linear regression equation was y=0.006 4c+0.005 5 with a linear regression coefficient(r) of 0.997 6 and a detection limit of 9.37×10-7 mol/L. This method could be used for the determination of captopril in tablets with satisfactory results. |
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| Keywords: | captopril o-phenanthroline photometry |
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