环糊精包合物表征手段的研究进展

环糊精分子具有独特的空间结构和高度选择性,在荧光分析、药物控制释放、手性识别、模拟酶、分子开关、超分子构筑等方面起着重要作用。环糊精与药物形成包合物后能大大增加药物的溶解度、生物利用度及实现靶向作用。现对研究环糊精和药物形成包合物的常用表征手段及其优缺点作一综述。

The Researching Progress of Exosyndrome Method Used in Studying Cyclodextrin Inclusion Complex

Cyclodextrin which has distinct molecular structure and many feasible derivatization makes it possible to design host moleculars which have special structure and higher selectivity according to their different purpose. These host moleculars play an important parts in the fluorescence analysis, drug controlled releasing, chiral recognition, mimic enzyme, molecular switch and supermolecular fabrication, etc. Cyclodextrin can improve solubility, bioavailability of drugs and realize targetting when it encapsulates drugs. Different methods for studying the inclusion complex between cyclodextrin and drugs are introduced in this paper. The advantage and disadvantage of the different methods are also discussed. The inclusion reaction between cyclodextrin and drugs is also prospected.