Isolation and chromosomal mapping of a mouse homolog of the Batten disease gene CLN3 |
| |
Authors: | RL Lee KR Johnson TJ Lerner |
| |
Affiliation: | Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown 02129, USA. |
| |
Abstract: | We describe the isolation and chromosomal mapping of a mouse homolog of the Batten disease gene, CLN3. Like its human counterpart, the mouse cDNA contains an open reading frame of 1314 bp encoding a predicted protein product of 438 amino acids. The mouse and human coding regions are 82 and 85% identical at the nucleic acid and amino acid levels, respectively. The mouse gene maps to distal Chromosome 7, in a region containing genes whose homologs are on human chromosome 16p12, where CLN3 maps. Isolation of a mouse CLN3 homolog will facilitate the creation of a mouse model of Batten disease. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|