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The start gene CDC28 and the genetic stability of yeast |
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| Authors: | A B Devin,V T Prosvirova TYu |
| Affiliation: | Institute of Molecular Genetics, U.S.S.R. Academy of Sciences, Moscow. |
| Abstract: | The cdc28-srm mutation in Saccharomyces cerevisiae decreases spontaneous and induced mitochondrial rho- mutability and the mitotic stability of native chromosomes and recombinant circular minichromosomes. The effects of cdc28-srm on the genetic stability of cells support the hypothesis that links cell cycle regulation in yeast to changes in chromatin organization dependent on the start gene CDC28 (Hayles and Nurse, 1986). |
| Keywords: | Saccharomyces cerevisiae cell cycle regulation CDC28 gene rho− mutation chromosome loss plasmid maintenance |