| 纳米羟基磷灰石/聚酰胺66复合材料药物缓释载体研究 |
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| 引用本文： | 彭雪林,李玉宝,张利,张志斌,吴坚.纳米羟基磷灰石/聚酰胺66复合材料药物缓释载体研究[J].功能材料,2006,37(10):1650-1652,1656. |
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| 作者姓名： | 彭雪林 李玉宝 张利 张志斌 吴坚 |
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| 作者单位： | 西南交通大学,生物工程学院,四川,成都,610031;四川大学,分析测试中心,四川,成都,610064 |
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| 摘 要： | 将纳米羟基磷灰石/聚酰胺66(n-HA/PA66)复合材料与抗生素类药物头孢哌酮钠(cefoperazone Sodium)复合,用特定溶剂将其调成糊状并自固化后,对该复合材料负载抗生素后的理化特性进行了研究.通过红外光谱及X射线衍射分析显示,载药材料保持了良好的化学稳定性.扫描电镜图象显示,材料表面及内部结构多孔.自固化n-HA/PA66复合材料在骨修复药物载体方面有很好的开发和应用前景.
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| 关 键 词： | 纳米羟基磷灰石 聚酰胺66 药物缓释 复合材料 |
| 文章编号： | 1001-9731（2006）10-1650-03 |
| 收稿时间： | 2006-03-15 |
| 修稿时间： | 2006-03-152006-07-28 |
Investigations on the self-setting nano-hydroxyapatite/polyamide 66 composite used as drug-controlling carrier |
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| PENG Xue-lin,LI Yu-bao,ZHANG Li,ZHANG Zhi-bin,WU Jian.Investigations on the self-setting nano-hydroxyapatite/polyamide 66 composite used as drug-controlling carrier[J].Journal of Functional Materials,2006,37(10):1650-1652,1656. |
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| Authors: | PENG Xue-lin LI Yu-bao ZHANG Li ZHANG Zhi-bin WU Jian |
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| Abstract: | A novel drug-controlling release system has been set up using cefoperazone sodium(CES) as a model drug and nano-hydroxyapatite/polyamide66 composite(n-HA/PA66) with self-setting property as the carrier,and the physico-chemical properties were characterized by means of IR,XRD and SEM. The results indicated that there was no obvious influence on the physio-chemical properties of the self-setting n-HA/PA66 composite after being loaded drug. The set composite showed porous structure,which was desirable for drug release from it.Furthermore,both the interior and exterior structures of the drug-containing material have not changed evidently.It can be concluded that the drug-containing composite has a potential to be utilized as local drug-controlled release carrier. |
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| Keywords: | nano-hydroxyapatite polyamide 66 composite drug release |
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