Synthesis of imidazo[1,2-a]pyridines as antiviral agents |
| |
| Authors: | A Gueiffier S Mavel M Lhassani A Elhakmaoui R Snoeck G Andrei O Chavignon JC Teulade M Witvrouw J Balzarini E De Clercq JP Chapat |
| |
| Affiliation: | Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Université de Tours, 31 Avenue Monge, 37200 Tours, France. |
| |
| Abstract: | The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
