Changes in lipid composition of liver microsomes and fatty acyl-CoA desaturase activities induced by medium chain triglyceride feeding |
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Authors: | José L Periago María L Pita María A Sanchez del Castillo Guillermo Caamaño María D Suárez |
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Affiliation: | 1. Departamento de Bioqui mica y Biologiá Molecular, Facultad de Ciencias, Fuentenueva s/n, 18071, Granada, Espa?a
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Abstract: | Changes in fatty acid composition, microsomal Δ9- and Δ6-desaturase activities and liver contents of cholesterol and phospholipids were studied in rats fed medium chain triglyceride-supplemented
diets. Weanling rats were divided into four groups and fed for three weeks a basal diet with different 10%-fat supplements:
corn oil, medium chain triglyceride-corn oil, olive oil and medium chain triglyceride-olive oil. The highest relative content
of saturated fatty acids corresponded to corn oil-fed animals. Both monounsaturated fatty acid content and Δ9-desaturase activity were higher in the animals fed olive oil diets than in corn oil-fed rats. The long chain polyunsaturated
fatty acids of the n−3 series were increased in the olive oil and medium chain triglyceride-olive oil-fed groups probably
due to the lower linoleic/α-linolenic ratios found in these two diets. The cholesterol/phospholipid molar ratio was unaffected
by diet and the unsaturation index was only slightly changed in the four groups. Thus, some mechanism may be operative under
these conditions to maintain the homeostasis of the membrane. |
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