| 7-氨基-3-去乙酰氧基头孢烷酸合成工艺的研究 |
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| 引用本文： | 付涛,郭英. 7-氨基-3-去乙酰氧基头孢烷酸合成工艺的研究[J]. 河北化工, 2009, 32(8): 19-21 |
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| 作者姓名： | 付涛 郭英 |
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| 作者单位： | 石家庄职业技术学院,河北,石家庄,050081 |
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| 摘 要： | 7-氨基-3-去乙酰氧基头孢烷酸是一种重要的头孢抗菌素医药中间体。讨论了青霉素G钾盐的氧化剂及扩环重排反应中的催化剂、扩环条件及头孢G酸的后处理,以优化其合成工艺。
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| 关 键 词： | 7-氨基-3-去乙酰氧基头孢烷酸 医药中间体 青霉素G钾盐 |
The Study of the Synthesized Technology of 7-amino-3-decase Toxycephalosporanic Acid |
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| FU Tao,GUO Ying. The Study of the Synthesized Technology of 7-amino-3-decase Toxycephalosporanic Acid[J]. Hebei Chemical Engineering and Industry, 2009, 32(8): 19-21 |
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| Authors: | FU Tao GUO Ying |
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| Affiliation: | Shijiazhuang Vocational Technology Institute;Shijiazhuang 050081;China |
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| Abstract: | 7-amino-3-decacetoxy cephalosporanic acid(7-ADCA) is a important medicine intermediate which can be used to synthesize a number of cef-antibiotics(such as ceftraixone,cefpodoxime,cefotaxime,ceftizoxime,and so on).This paper discussed the oxidizing agent of penicillin G sylvite,the catalyst of reaction of ring-expending,the conditions of Ring-Expending,and the post-treatment of them to improve the synthesized technology of 7-ADCA. |
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| Keywords: | 7-amino-3-desacetoxy cephalosporanic acid medicine intermediate penicillin G potassium |
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