SPG膜乳化与界面聚合法制备单分散多孔微囊膜

小粒径单分散中空储库结构微囊膜的制备具有重要学术意义和实用价值。为此采用了SPG(Shirasu-Porous-Glass)膜乳化法和界面聚合法，对小粒径单分散多孔微囊膜的制备进行了较系统的实验研究，以期为进一步制备多孔内接枝环境感应型功能凝胶开关的小粒径单分散微囊型靶向式药物载体提供基体。研究结果表明，采用SPG膜乳化法可制得单分散性良好的乳液液滴，进而采用界面聚合法可得到单分散微囊。用膜乳化方法易于控制乳液液滴及微囊的大小，在研究中SPG膜乳化法制备的乳液液滴及微囊的平均粒径大约是所用膜孔径的3．6倍。微囊膜的多孔性可以靠改变溶剂和单体的成分来进行控制，扫描电镜检测结果表明所制备出的不同粒径级别的单分散微囊膜均具有良好的多孔结构。

Preparation of Monodispersed Porous Microcapsule Membranes with SPG Membrane Emulsification and Interfacial Polymerization

The fabrication of small-size monodispersed microcapsules (or hollow reservoirs) that enable the encapsulation of various materials is of both scientific and technological interest. Experimental investigations were carried out systematically to prepare small-sized, monodispersed and porous microcapsule membranes by using SPG (Shirasu-Porous-Glass) membrane emulsification and interfacial polymerization. The object of this study is to offer small-sized monodispersed porous microcapsule matrix for further preparation of targeting-type drug carrier, in which stimuli-responsive hydrogel will be grafted into the pores as switch. The experimental results showed that monodispersed emulsions can be resulted from the SPG membrane emulsification, and then monodispersed microcapsules can be obtained after the interfacial polymerization. The granule diameter of prepared microcapsules was generally as about 3.6 times as the pore diameter of SPG membrane in this study. The porosity and the pore size of the microcapsule membrane can be controlled by selecting proper ingredients of the solvent and monomers. Scanning electron micrographs (SEM) indicated that the prepared monodispersed microcapsule membranes of different size grades are all featured with satisfactory porous structure.