Preparation of polymer-supported amino acid

Summary Insoluble polymer-supported amino acids have been synthesized by simple one-pot synthesis. Amino acids were solubilized in organic solvent by trimethylsilylation. Solubilized amino acids (L-Tyr, L-Ser, D-HPG, L-Cys) having functional groups such as OH or SH were easily attached to crosslinked polystyrene beads through benzyl ether or thioether linkage. Other amino acids without extra functional groups could be attached to the polymer through benzyl amine linkage.