| 载碘胺铂壳聚糖微球的制备及其抗人肝癌细胞活性研究 |
| |
| 引用本文： | 李倩,吴庆生. 载碘胺铂壳聚糖微球的制备及其抗人肝癌细胞活性研究[J]. 材料导报, 2015, 29(14): 40-44, 51. DOI: 10.11896/j.issn.1005-023X.2015.14.009 |
| |
| 作者姓名： | 李倩 吴庆生 |
| |
| 作者单位： | 1. 上海市质量监督检验技术研究院,上海201114;同济大学化学系长江水环境教育部重点实验室,上海200092;2. 同济大学化学系长江水环境教育部重点实验室,上海,200092 |
| |
| 基金项目： | “十二五”国家科技支撑计划项目(2013BAK04B04-03) |
| |
| 摘 要： | 采用乳化交联法制备了载碘胺铂壳聚糖微球,用扫描电镜和红外光谱对其结构及形貌进行了表征。载碘胺铂壳聚糖微球的平均载药量为(46.48±4.42)%,平均包封率为(91.39±2.45)%,缓释测试符合一级释药方程。MTT实验证明载碘胺铂壳聚糖微球能抑制肝癌细胞生长,且比单纯使用碘胺铂高。
|
| 关 键 词： | 壳聚糖微球 乳化交联法 缓释 MTT 碘胺铂 |
Preparation of Cis-DIDP-loaded Chitosan Microspheres and Its Anti Human Hepatocellular Carcinoma Cell Activity |
| |
| LI Qian and WU Qingsheng. Preparation of Cis-DIDP-loaded Chitosan Microspheres and Its Anti Human Hepatocellular Carcinoma Cell Activity[J]. Materials Review, 2015, 29(14): 40-44, 51. DOI: 10.11896/j.issn.1005-023X.2015.14.009 |
| |
| Authors: | LI Qian and WU Qingsheng |
| |
| Affiliation: | Shanghai Institute of Quality Inspection and Technical Research, Shanghai 201114;Ministry of Education,Key Laboratory of Yangtze River Water Environment, Department of Chemistry, Tongji University, Shanghai 200092 and Ministry of Education,Key Laboratory of Yangtze River Water Environment, Department of Chemistry, Tongji University, Shanghai 200092 |
| |
| Abstract: | Cis-DIDP-loaded chitosan (CS) microspheres were prepared by emulsion crosslinking method,and their structure and morphology were characterized by means of SEM, IR and UV. The drug loading capacity of cis-DIDP-loaded CS microspheres was (46.48±4.42)%, and their encapsulation efficiency was (91.39±2.45)%. In vitro drug release exhibited first-order release of drugs. MTT assay results showed that cis-DIDP released from cis-DIDP-loaded CS microspheres had better inhibition activity than cis-DIDP that had not been loaded. |
| |
| Keywords: | chitosan microspheres emulsion crosslinking method controlled release MTT cis-DIDP |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《材料导报》浏览原始摘要信息 |
|
点击此处可从《材料导报》下载全文 |
|
