Effects of renal factors on in vitro hepatic cholesterol synthesis in the rat |
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Authors: | Guy T Haven Herbert P Jacobi |
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Affiliation: | (1) Departments of Biochemistry and Pathology, The University of Nebraska College of Medicine, 42nd and Dewey Avenue, Omaha, 68105 Nebraska |
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Abstract: | Two products derived from rat renal tissue have been shown to affect in vitro hepatic cholesterol synthesis. A premevalonate
inhibitor of hepatic cholesterol synthesis is associated with the membranes of the renal endoplasmic reticulum. It is stable
at −75 C and at 4 C but is heat labile. A pre-mevalonate stimulator of in vitro hepatic cholesterol synthesis is located within
renal lysosomes and can be prepared in a nonsedimentable form by extraction with hypotonic buffer. While it is stable at −75
C, it loses activity at 4 C. Both of these products appear to have a molecular weight in excess of 150,000 as determined by
gel filtration.
Deceased. |
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Keywords: | |
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