Impaired verbal comprehension of quantifiers in corticobasal syndrome.

Objective: Patients with Corticobasal Syndrome (CBS) have atrophy in posterior parietal cortex. This region of atrophy has been previously linked with quantifier comprehension difficulty, but previous studies employed visual stimuli, making it difficult to account for potentially confounding visuospatial deficits in CBS patients. The current study evaluated comprehension of generalized quantifiers using strictly verbal materials. Method: Non-aphasic CBS patients, a brain-damaged control group (consisting of patients with Alzheimer's disease and frontotemporal dementia), and age-matched healthy controls participated in this study. We assessed familiar temporal, spatial, and monetary domains of verbal knowledge comparatively. Judgment accuracy was only evaluated in statements for which patients demonstrated accurate factual knowledge about the target domain. Results: We found that patients with CBS are significantly impaired in their ability to evaluate quantifiers when compared to healthy seniors and a brain-damaged control group, even in this strictly verbal task. This impairment was seen in the vast majority of individual CBS patients. Conclusions: These findings offer additional evidence of quantifier impairment in CBS patients and emphasize that this impairment cannot be attributed to potential visuo spatial processing impairments in patients with parietal disease. (PsycINFO Database Record (c) 2011 APA, all rights reserved)