| 5,6-二甲基苯并咪唑的合成工艺改进 |
| |
| 引用本文： | 苏砚溪,杨纪清. 5,6-二甲基苯并咪唑的合成工艺改进[J]. 精细化工, 2001, 18(2): 76-77,97 |
| |
| 作者姓名： | 苏砚溪 杨纪清 |
| |
| 作者单位： | 河北师范大学化学系, |
| |
| 摘 要： | 以 3,4 二甲基苯胺为母体 ,合成了 5 ,6 二甲基苯并咪唑。产品收率达 41%。在乙酰化、硝化反应中引入了 1,2 二氯乙烷溶剂。用正交实验确定了最佳原料配比 :n(3,4 二甲基苯胺 )∶n(醋酐 )∶n(硫酸 ) =1 0 0∶1 30∶1 13。改进后 ,每mol母体的醋酐用量由 30 3 0g减少至 132 6g ,浓硫酸用量由 30 3 8g减少至 110 74g。
|
| 关 键 词： | 5,6-二甲基苯并咪唑 3,4-二甲基苯胺 乙酰化 |
| 文章编号： | 1003-5214(2001)02-0076-03 |
Improved Technology for Synthesis of 5,6-Dimethylbenzimidazole |
| |
| SU Yan-xi,YANG Ji-Qing. Improved Technology for Synthesis of 5,6-Dimethylbenzimidazole[J]. Fine Chemicals, 2001, 18(2): 76-77,97 |
| |
| Authors: | SU Yan-xi YANG Ji-Qing |
| |
| Abstract: | 5,6-Dimethylbenzimidazole was synthesized with 3,4 -dimethylaniline as raw material.The yield of product was over 41%.In the react ion of acetylation and nitration 1,2-dichloroethane was used as solvent.The opt imal molar ratio of reactants was 3,4-dimethylaniline∶acetic anhydride∶sulfuric a cid=1.00∶1.30∶1.13.In this improved technology, amount of acetic anhydride was reduced from 303 g to 132.6 g,and amount of sulf uric acid was reduced from 303.8g to 110.74 g for each mole of 3,4-dimethylanilin e. |
| |
| Keywords: | dimethylbenzimidazole 3 4 dimethylaniline acetylation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
