5-Fluorouracil derivatives. XXII. Synthesis and antitumor activities of 1-carbamoyl-5-fluorouracils |
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| Authors: | S Ozaki X Kong Y Watanabe T Hoshiko T Koga T Ogasawara T Takizawa H Fujisawa M Iigo A Hoshi |
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| Affiliation: | Department of Chemistry, Shandong University, Jinan, China. |
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| Abstract: | Fifty-four 1-carbamoyl-5-fluorouracils were synthesized from 5-fluorouracil and isocyanate or amine. Antitumor activity was tested in the L-1210 tumor system, and 11 compounds gave better values of therapeutic ratio than HCFU (1-hexylcarbamoyl-5-fluorouracil). 1-(4-Methoxycyclohexylcarbamoyl)-5-fluorouracil gave the best result. |
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