Effect of cholestyramine on bile acid metabolism in conventional rats |
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Authors: | Yasuharu Imai Sumio Kawata Masami Inada Shio Miyoshi Yuzo Minami Yuji Matsuzawa Kiyohisa Uchida Seiichiro Tarui |
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Affiliation: | (1) Shionogi Research Laboratories, Osaka, Japan;(2) The Second Department of Internal Medicine, Osaka University Medical School, Fukushima-ku, 553 Osaka, Japan |
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Abstract: | Effects of cholestyramine on biliary secretion of cholesterol, phospholipids and bile acids and fecal excretion of sterols
and bile acids were examined in Wistar male rats. Six rats were fed a basal diet, and the other six were fed a basal diet
supplemented with 5% cholestyramine for eight days. Bile flow and biliary secretion of bile acids and phospholipids (per hour
per rat) decreased with cholestyramine treatment, while biliary cholesterol secretion (per hour per rat) remained unchanged.
In the biliary bile acid composition, a marked increase of chenodeoxycholic acid with a concomitant decrease of β-muricholic
acid was observed in cholestyramine-treated rats. Fecal excretion of total sterols and bile acids increased about three-and
four-fold, respectively, after cholestyramine treatment. The increase of fecal bile acids derived from cholic acid was more
predominant than that derived from chenodeoxylcholic acid, resulting in an increase of the cholic acid group/chenodeoxycholic
acid group ratio. |
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