| 人端粒酶催化亚单位(hTERT)反义分子探针的制备与理化性质初步研究 |
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| 引用本文： | 王荣福,刘萌,张春丽,闫平.人端粒酶催化亚单位(hTERT)反义分子探针的制备与理化性质初步研究[J].核化学与放射化学,2010,32(1):35-40. |
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| 作者姓名： | 王荣福 刘萌 张春丽 闫平 |
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| 作者单位： | 北京大学第一医院 核医学科，北京100034 |
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| 基金项目： | 高等学校博士学科点专项科研基金资助项目(20050001108);;教育部教育振兴行动计划特殊专项(“九八五”工程:Ⅱ期)资助项目(985-2-056);;国家自然科学基金资助项目(30670583,30470498,30900374);;国家重点基础研究发展计划(“973”计划)资助项目(2006CB705705);;高等学校博士学科点专项科研基金新教师基金课题(200800011061) |
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| 摘 要： |
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| 关 键 词： | 人端粒酶催化亚单位（hTERT） S-AcetylNHS-MAG3 99Tcm 分子探针 反义显像 |
Preparation and Characterization of 99Tcm-Labeled Antisense Oligonucleotide Targeting hTERT mRNA |
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| WANG Rong-fu,LIU Meng,ZHANG Chun-li,YAN Ping.Preparation and Characterization of 99Tcm-Labeled Antisense Oligonucleotide Targeting hTERT mRNA[J].Journal of Nuclear and Radiochemistry,2010,32(1):35-40. |
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| Authors: | WANG Rong-fu LIU Meng ZHANG Chun-li YAN Ping |
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| Affiliation: | Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China |
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| Abstract: | To radiolabel antisense oligonucleotide(ASON) targeting hTERT mRNA with technetium-99m,and evaluate the characteristics of this novel radiopharmaceutical.One 18mer antisense uniformly phosphorothioate-modified oligonucleotide targeting hTERT mRNA was radiolabeled with technetium-99m through bifunctional chelator N-hydroxysuccinimidyl derivative of S-acetylmercaptoacetyltriglycine(S-Acetyl NHS-MAG3).The novel molecular imaging agent was characterized in vitro.All data were analyzed by the statistic software ... |
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| Keywords: | S-Acetyl NHS-MAG3 99Tcm |
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