| 氟苯咪唑合成工艺的改进 |
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| 引用本文： | 李普瑞,刘敏,刘鸿.氟苯咪唑合成工艺的改进[J].应用化工,2004,33(3):63-64. |
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| 作者姓名： | 李普瑞 刘敏 刘鸿 |
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| 作者单位： | 西安近代化学研究所,陕西,西安,710065 |
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| 摘 要： | 研究了以3,4 二氨基 4′ 氟二苯酮和O 甲基异脲甲酸甲酯反应合成氟苯咪唑的工艺改进。采取分段升温 中间过滤法,提高了产品质量,收率大幅增加,与原工艺相比,总收率增加16个百分点,可达80.5%。实验证明,该工艺简单可靠,质量稳定,具有工业生产价值。
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| 关 键 词： | 氟苯咪唑 合成 改进 |
| 文章编号： | 1671-3206(2004)03-0063-02 |
| 修稿时间： | 2003年10月28 |
Improvement on process for synthesizing flubenimidazole |
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| LI Pu-rui,LIU Min,LIU Hong.Improvement on process for synthesizing flubenimidazole[J].Applied chemical industry,2004,33(3):63-64. |
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| Authors: | LI Pu-rui LIU Min LIU Hong |
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| Abstract: | The improved process that flubenimidazole was prepared by the reaction of (3,4-diaminophenyl) (4-fluorophenyl) methanone with-o-methyl-isourea methyl formate was described. According to this method, the reaction temperature was increased by two steps , and the intermediate was filtrated. The results showed that the quality of product was improved and the yied was raised.Compared with original process, the total yield was raised 16%, it reached 80.5%. It was testified that the improved process was simple and reliable, and the product quality was stable . It can be used in the manufacture. |
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| Keywords: | flubenimidazole synthesis improvement |
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