Study of omeprazole-gamma-cyclodextrin complexation in the solid state |
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| Authors: | Arias M J Moyano J R Muñoz P Ginés J M Justo A Giordano F |
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| Affiliation: | a Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, Spainb Institute for Materials Science, CSIC-University of Seville, Seville, Spainc Pharmaceutical Department, Faculty of Pharmacy, University of Parma, Parma, Italy |
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| Abstract: | The possibility of obtaining inclusion complexes between omeprazole (OME) and γ-cyclodextrin (γ-CD) by kneading, spray-drying, coprecipitation, and freeze-drying was evaluated. All these methods lead to the isolation of a true inclusion compound, as evidenced by differential scanning calorimetry (DSC), infrared spectroscopy, and X-ray diffractometry on powder (PXRD). Moreover, PXRD and scanning electron microscopy (SEM) afforded data concerning crystallinity and surface characteristics of the solid phases obtained. In all cases, a significant increase of the release rate with respect to the drug alone was found, and it was attributed to the formation of an inclusion compound. Among the solid phases obtained, the coprecipitated product presented the highest dissolution rate. |
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| Keywords: | γ-CD Dissolution rate DSC Inclusion complex Omeprazole PXRD |
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