Formulation and Development of Self-Nanoemulsifying Granules of Olmesartan Medoxomil for Bioavailability Enhancement |
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| Authors: | Jaydeep Patel Anjali Dhingani Jay Tilala Mihir Raval Navin Sheth |
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| Affiliation: | 1. Department of Pharmaceutics , Atmiya Institute of Pharmacy , Rajkot , Gujarat , India;2. Department of Pharmaceutical Sciences , Saurashtra University , Rajkot , Gujarat , India |
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| Abstract: | The present investigation was aimed to formulate self-nanoemulsifying granules (SNEGs) of poorly water soluble drug, Olmesartan Medoxomil (OLM) to improve its solubility and oral bioavailability. Acconon sorb 20, Tween 80, and Carbitol were selected as oil, surfactant and cosurfactant, respectively for the development of liquid self-nanoemulsifying system (L-SNEDDS), which subsequently adsorbed on a carrier (Aerosil 200) to develop SNEGs. The results of in vitro and in vivo study of OLM-SNEGs revealed remarkable improvement compared to pure OLM. The present study proposed SNEGs as one of the suitable approach for developing nanosized solid oral dosage forms of OLM. |
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| Keywords: | Bioavailability Box-Behnken design Olmesartan medoxomil oral drug delivery self-nanoemulsifying granules |
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