A Coating‐Free Nonfouling Polymeric Elastomer |
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Authors: | Hsiang‐Chieh Hung Priyesh Jain Peng Zhang Fang Sun Andrew Sinclair Tao Bai Bowen Li Kan Wu Caroline Tsao Erik J. Liu Harihara S. Sundaram Xiaojie Lin Payam Farahani Timothy Fujihara Shaoyi Jiang |
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Affiliation: | Department of Chemical Engineering, University of Washington, Seattle, WA, USA |
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Abstract: | Medical devices face nonspecific biofouling from proteins, cells, and microorganisms, which significantly contributes to complications and device failure. Imparting these devices with nonfouling capabilities remains a major challenge, particularly for those made from elastomeric polymers. Current strategies, including surface coating and copolymerization/physical blending, necessitate compromise among nonfouling properties, durability, and mechanical strength. Here, a new strategy is reported to achieve both high bulk mechanical strength and excellent surface nonfouling properties, which are typically contradictory, in one material. This is realized through a nonfouling polymeric elastomer based on zwitterionic polycarboxybetaine derivatives. By hiding both charged moieties of the zwitterionic compounds with hydrocarbon ester and tertiary amine groups, the bulk polymer itself is elastomeric and hydrophobic while its superhydrophilic surface properties are restored upon hydrolysis. This coating‐free nonfouling elastomer is a highly promising biomaterial for biomedical and engineering applications. |
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Keywords: | coating‐free elastomers nonfouling zwitterionic |
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