Manganese‐Based Layered Double Hydroxide Nanoparticles as a T1‐MRI Contrast Agent with Ultrasensitive pH Response and High Relaxivity |
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Authors: | Bei Li Zi Gu Nyoman Kurniawan Weiyu Chen Zhi Ping Xu |
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Affiliation: | 1. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia;2. School of Chemical Engineering, The University of New South Wales, Sydney, NSW, Australia;3. Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia |
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Abstract: | Recently, Mn(II)‐containing nanoparticles have been explored widely as an attractive alternative to Gd(III)‐based T1‐weighted magnetic resonance imaging (MRI) contrast agents (CAs) for cancer diagnosis. However, as far as it is known, no Mn‐based MRI CAs have been reported to sensitively respond to a very weakly acidic environment (pH 6.5–7.0, i.e., the pH range in a tumor microenvironment) with satisfactory imaging performance. Here, recently devised pH‐ultrasensitive Mn‐based layered double hydroxide (Mn‐LDH) nanoparticles with superb longitudinal relaxivity (9.48 mm ?1 s?1 at pH 5.0 and 6.82 mm ?1 s?1 at pH 7.0 vs 1.16 mm ?1 s?1 at pH 7.4) are reported, which may result from the unique microstructure of Mn ions in Mn‐LDH, as demonstrated by extended X‐ray absorption fine structure. Further in vivo imaging reveals that Mn‐LDH nanoparticles show clear MR imaging for tumor tissues in mice for 2 d post intravenous injection. Thus, this novel Mn‐doped LDH nanomaterial, together with already demonstrated capacity for drug and gene delivery, is a very potential theranostic agent for cancer diagnosis and treatment. |
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Keywords: | contrast agents high relaxivity pH response theranostic agents |
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