Excessive fibrinolysis: the coagulopathy following Merrem's hump-nosed viper (Hypnale hypnale) bites |
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| Authors: | AP Premawardena SL Seneviratne SB Gunatilake HJ de Silva |
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| Affiliation: | Corneal and Refractive Surgery Services, Massachusetts Eye and Ear Infirmary, and Schepens Eye Research Institute, Harvard Medical School, Boston 02114-3096, USA. dimitri_azar@meei.harvard.edu |
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| Abstract: | In 56 patients with proven hump-nosed viper (Hypnale hypnale) bites, 12 (21.4%) developed continued oozing of blood from the site of the bite and a prolonged clotting time. Further investigations showed low fibrinogen levels and increased fibrinogen degradation products in plamsa. The bleeding time, platelet count, prothrombin time, and partial thromboplastin time with kaolin were normal. The bite of this snake can be complicated with a coagulopathy in which excessive fibrinolysis seems to be the main abnormality. |
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