Involvement of brain serotonergic function in lidocaine-induced convulsions in mice |
| |
Authors: | K Endo K Morita Y Uchiyama K Takada A Tsujimoto T Dohi |
| |
Affiliation: | Department of Oral and Maxillofacial Surgery, Hiroshima University School of Dentistry, Japan. |
| |
Abstract: | Influences of drug-induced manipulations of central serotonergic function on lidocaine- and pentylenetetrazol (PTZ)-induced convulsions were examined in mice. Agents that suppressed serotonergic transmission increased, whereas drugs that facilitated serotonin (5-HT) function decreased the incidence of lidocaine-induced convulsions. These treatments had similar influences on the incidence of PTZ-induced convulsions. Lidocaine (10(-5)-10(-3) M) reduced the stimulation evoked [3H]5-HT release from cortical slices, followed with an increased spontaneous [3H] overflow at higher concentrations. These results may suggest that brain 5-HT neurons are causally involved as inhibitory neurons in lidocaine-induced convulsions as in the case of PTZ-induced convulsions. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|