Age-related changes in biological parameters in Zucker rats |
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Authors: | André Bach Henri Schirardin Marthe Bauer Adrien Schaeffer André Weryha |
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Affiliation: | 1. Laboratoire de Pathologie Générale, Service de Médecine Interne A, Clinique Médicale A, H?pital Civil, 67091, Strasbourg Cedex, France
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Abstract: | Changes in a number of morphological and biochemical parameters were observed in genetically obese Zucker rats and in lean
controls between 3 and 58 weeks of age. By 3 weeks, the genetically obese rats had higher proportional (wt/100 g body wt)
and absolute amounts of adipose tissue, hyperlipemia affecting all the lipid fractions, and hyperproteinemia compared to lean
controls. Obesity, hepatomegaly, high concentrations of hepatic lipids and hyperinsulinemia did not appear until the fifth
week. In obese animals, liver lipid concentration reached a maximum at 17 weeks of age and then declined. During this time,
the triacylglycerol concentrations in the serum remained stable, whereas the cholesterol and phospholipid concentrations continued
to increase. The glycogen concentration in obese animals increased, both absolutely and compared to lean controls, between
the 12th and 43rd week of age. From weaning, the Zucker rats, compared to lean controls, exhibited characteristics of obesity
(accumulation of adipose tissue, hyperlipemia and hyperproteinemia), which persisted to the age of 58 weeks. |
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