| 1,2-二苯氧基乙烷的合成及工艺 |
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| 引用本文： | 曹育才,朱汕.1,2-二苯氧基乙烷的合成及工艺[J].精细化工,2010,27(5). |
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| 作者姓名： | 曹育才 朱汕 |
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| 作者单位： | 上海化工研究院,上海,200062 |
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| 基金项目： | 上海市科委科技计划资助项目(04cg51005,065211021,09QB1401800)~~ |
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| 摘 要： | 采用水相体系直接合成得到高纯度的1,2-二苯氧基乙烷,在优化工艺条件下,以1,2-二溴乙烷和苯酚为基本原料,KOH为碱,1,2-二苯氧基乙烷摩尔收率达75%,产品气相色谱纯度达99%,且完成了10 kg/批的扩大合成实验评价,效果稳定。最优合成工艺为:反应时间25 h,w(KOH)=50%的水溶液,n(KOH)∶n(苯酚)∶n(1,2-二溴乙烷)=3.0∶3.0∶1.0,反应温度60℃。在该条件下,产物中杂质的生成量较少。
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| 关 键 词： | 1 2-二苯氧基乙烷 乙二醇二苯醚 对称双醚 |
| 收稿时间： | 2010/1/10 0:00:00 |
| 修稿时间： | 2010/2/11 0:00:00 |
Synthesis of 1,2-diphenoxyethane and optimized process |
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| CAO Yu-cai and Zhu Shan.Synthesis of 1,2-diphenoxyethane and optimized process[J].Fine Chemicals,2010,27(5). |
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| Authors: | CAO Yu-cai and Zhu Shan |
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| Affiliation: | Shanghai Research Institute of Chemical Industry/a>;Shanghai 200062/a>;China |
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| Abstract: | 1,2-Diphenoxyethane with high purity was successfully synthesized by 1,2-dibromoethane reacting with phenol in the aqueous KOH solution.Under the optimized reaction conditions,the molar yield of 1,2-diphenoxyethane exceeding 75% on the basis of 1,2-dibromoethane and GC purity exceeding 99% were achieved.This attractive result was confirmed by a series of scale-up test with 10 kg/batch size.The following optimized conditions were obtained: the optimized reaction time is 25 h,the concentration of base is w(KO... |
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| Keywords: | 1 2-diphenoxyethane diphenyl glycol ether symmetric diether |
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