| 类酶催化反应中手性碳原子取代基的空间效应 |
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| 引用本文： | 张革新,张景尧,刘松琴,郑秋容,朴银实,曹阳.类酶催化反应中手性碳原子取代基的空间效应[J].食品与生物技术学报,1999,18(1). |
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| 作者姓名： | 张革新 张景尧 刘松琴 郑秋容 朴银实 曹阳 |
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| 作者单位： | 无锡轻工大学化工系，苏州大学化学化工学院 |
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| 摘 要： | 结合手性碳原子取代基体积相对大小，及其产生的空间效应，研究了催化剂癸酰基－Ｌ－组氨酸（Ｄｅｃ－Ｌ－Ｈｉｓ）分别与Ｌ型Ｄ型底物即苄酯基－Ｌ－苯丙氨酸对硝基苯酚酯和苄酯基－Ｄ－苯丙氨酸对硝基苯酚酯（ＮＰＥ－Ｌ－ＣＢＺ－Ｐｈｅ和ＮＰＥ－Ｄ－ＣＢＺ－Ｐｈｅ）所形成中间物的稳定性，指出实验中催化剂立体选择性即Ｌ型底物占优势的原因，同时也说明所提机理的可靠性。
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| 关 键 词： | 类酶催化 手性碳原子 取代基 空间效应 |
Steric Effect of Chiral Carbon Replacing Group in the Similar Enzyme Reaction |
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| Zhang Gexin,Zhang Jingyao,Liu Songqin,Zheng Qiurong,Piao Yingshi.Steric Effect of Chiral Carbon Replacing Group in the Similar Enzyme Reaction[J].Journal of Food Science and Biotechnology,1999,18(1). |
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| Authors: | Zhang Gexin Zhang Jingyao Liu Songqin Zheng Qiurong Piao Yingshi |
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| Abstract: | In the previous article,we first explored similar enzyme reaction with quantum chemistry and a reasonable pathway has been proposed.In this paper,we studied volume and steric effect chiral carbon replacing group in this reaction.The results show that complex of NPE L CBZ Phe and Dec L His is more stable than that of NPE D CBZ Phe and Dec L His.This is why catalyst has a great stereselectivity to L substrate in experiment. On the other hand,the reasonable pathway reported previously has been supported again. |
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| Keywords: | similar enzyme chiral carbon replacing group space effect |
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