| 2,3-二氯苯甲酸的合成研究 |
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| 引用本文： | 廖齐,邓洪.2,3-二氯苯甲酸的合成研究[J].精细化工中间体,2006,36(4):18-20. |
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| 作者姓名： | 廖齐 邓洪 |
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| 作者单位： | 中南林业科技大学,理学院,湖南,株洲,412006 |
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| 基金项目： | 中南林学院引进高层次人才科研基金项目(0113) |
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| 摘 要： | 2,3-二氯苯甲酸是合成特效抗癫痫药拉莫三嗪及其它治疗中枢神经紊乱药物的重要中间体。笔者用2,3-二氯苯胺经重氮化、迈尔瓦音反应制得2,3-二氯苯甲醛,再经高锰酸钾氧化制得2,3-二氯苯甲酸,总收率45%。对各步反应的操作及产品的纯化方法进行了研究。
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| 关 键 词： | 2 3-二氯苯甲酸 2 3-二氯苯甲醛 抗癫痫 拉莫三嗪 中间体 合成 |
| 文章编号： | 1009-9212(2006)04-0018-03 |
| 修稿时间： | 2006-06-05 |
Synthesis of 2,3-Dichlorobenzoic Acid |
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| LIAO Qi,DENG Hong.Synthesis of 2,3-Dichlorobenzoic Acid[J].Fine Chemical Intermediates,2006,36(4):18-20. |
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| Authors: | LIAO Qi DENG Hong |
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| Affiliation: | Department of Chemistry, Central South University of Forestry and Technology, Zhuzhou 412006, China |
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| Abstract: | 2,3-Dichlorobenzoic acid is the key intermediate for antiepileptic drug lamotrigine and the other medicine for the treatment of central nervous system (CNS)disorders and disease. 2,3-Dichlorobenzoic acid was prepared through diazotization and Meerwein reaction to give 2,3-dichlorobenzaldehyde from 2,3-dichloroaniline and followed by oxidation with potassium permanganate,and the overall yield was 45%. In addition,each operation of the reactions and purification was also studied . |
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| Keywords: | 2 3-dichlorobenzoic acid 2 3-dichlorobenzaldehyde antiepileptic lamotigine intermediate synthesis |
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