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Biomimetic Membrane System Composed of a Composite Interpenetrating Hydrogel Film and a Lipid Bilayer |
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| Authors: | Barry Stidder Jean‐Pierre Alcaraz Lavinia Liguori Nawel Khalef Aziz Bakri Erik B Watkins Philippe Cinquin Donald K Martin |
| Affiliation: | 1. Fondation RTRA Nanosciences, Université Joseph Fourier‐Grenoble 1/CNRS/TIMC‐IMAG UMR 5525, Grenoble, F‐38041, France;2. Université Joseph Fourier‐Grenoble 1/CNRS/TIMC‐IMAG UMR 5525, Grenoble, F‐38041, France;3. Université Joseph Fourier‐Grenoble 1/CNRS/TIMC‐IMAG UMR 5525/TheREx/Formulation and Pharmaceutical, Formulation Engineering, Grenoble, F‐38041, France;4. Institut Laue‐Langevin, 6, rue Jules Horowitz, Grenoble, F‐38042, France |
| Abstract: | A simple way to form an interpenetrating hydrogel (IPH) by combining a layer‐by‐layer polyelectrolyte membrane with agarose is reported. The formed IPH membrane is more robust and easily manipulated compared to a polyelectrolyte membrane with the same number of layers. The IPH has good diffusion characteristics and retains the advantageous surface charge from the polyectrolyte composition that facilitates the adsorption of a stable lipid bilayer. The stable adsorption of a lipid bilayer on the IPH creates a biomimetic membrane system that is optimized for utilization in a diffusion chamber. |
| Keywords: | biomimetic membrane interpenetrating hydrogel polyelectrolyte layer‐by‐layer agarose |