Preparation of ibuprofen/lipid composite microparticles by supercritical fluid technique |
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Authors: | Xia WANG Hui CHEN Yanni GUO Yuzhong SU Hongtao WANG Jun LI |
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Affiliation: | (1) Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China |
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Abstract: | Using the CO2-and N2-assisted atomization processes, the production of ibuprofen/lipid composite microparticles is investigated, in which the
lipid includes myristic acid and tripalmitin. The produced composite particles show similar morphology to that of the purelipids
obtained by the same process. In the case of the N2-assisted process, the average size of composite particles is slightly larger than that of the pure lipid particles due to
the difficulty of solidification when using N2. In the case of the CO2-assisted process, the average size of composite particles is slightly smaller than that of the pure myristic acid particles,
but slightly larger than that of the pure tripalmitin particles. The dissolution study reveals that the drug release from
the ibuprofen/myristic acid particles is enhanced in comparison with that of the unprocessed ibuprofen. For the particles
produced by the N2-assisted process, the X-ray diffraction (XRD) patterns clearly indicate the encapsulation of ibuprofen into myristic acid.
The obtained ibuprofen/tripalmitin composite particles with 5% or 20% of ibuprofen (in mass) evidently show the controlled
drug release: only about 20% of the drug is released in 500 min from the ibuprofen/tripalmitin composite particles consisting
of 20% ibuprofen prepared by the CO2-assisted process, and the same release is obtained from the ibuprofen/tripalmitin composite particles containing 5% ibuprofen
prepared by the N2-assisted process.
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Translated from Modern Chemical Industry, 2007, 27(Suppl. 2): 398–402 译自: 现代化工] |
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Keywords: | supercritical fluids composite microparticles ibuprofen myristic acid tripalmitin |
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