Anti-inflammatory drugs interacting with Zn(II), Cd(II) and Pt(II) metal ions |
| |
Authors: | C Dendrinou-Samara G Tsotsou LV Ekateriniadou AH Kortsaris CP Raptopoulou A Terzis DA Kyriakidis DP Kessissoglou |
| |
Affiliation: | Department of Chemistry, Aristotle University of Thessaloniki, Greece. |
| |
Abstract: | Complexes of Zn(II), Cd(II) and Pt(II) metal ions with the anti-inflammatory drugs, 1-methyl-5-(p-toluoyl)-1H-pyrrole-2-acetic acid (Tolmetin), alpha-methyl-4-(2-methylpropyl)benzeneacetic acid (Ibuprofen), 6-methoxy-alpha-methylnaphthalene-2-acetic acid (Naproxen) and 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid (indomethacin) have been synthesized and characterized. In the structurally characterized Cd(naproxen)2 complex the anti-inflammatory drugs acts as bidentate chelate ligand coordinatively bound to metal ions through the deprotonated carboxylate group. Crystal data for 1: [C32H26O8Cd], orthorhombic, space group P22(1)2(1), a = 5.693(2) (A), b = 8.760(3) (A), c = 30.74(1) (A), V = 1533(1) A3, Z = 2. Antibacterial and growth inhibitory activity is higher than that of the parent ligands or the platinum(II) diamine compounds. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|