The phenotype of SLE associated with complete deficiency of complement isotype C4A |
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Authors: | TR Welch C Brickman N Bishof S Maringhini M Rutkowski M Frenzke N Kantor |
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Affiliation: | Department of Pathology, County Hospital of Zala, Zalaegerszeg, Hungary. |
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Abstract: | Authors present a multiparameter pathological study in a case of rapid biclonal primary plasma cell leukemia. The immunohistochemical data revealed aberrant phenotypes (monocyte, epithelial and T-cell) probably in connection with microenvironmental influences. Biclonality can be attributed to class switching during malignant transformation. Static image cytometry showed aneuploidy. The blasts of this process are active immunoregulatory cells. |
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