Taurine ameliorates alcoholic steatohepatitis via enhancing self-antioxidant capacity and alcohol metabolism |
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| Authors: | Yi-Jen Fang Chih-Hsien Chiu Yuan-Yen Chang Chung-Hsi Chou Hui-Wen Lin Ming-Feng Chen Yi-Chen Chen |
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| Affiliation: | aDivision of Gastroenterology, Department of Medicine, Show Chwan Memorial Hospital, Changhuan 500, Taiwan;bDepartment of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan;cDepartment of Microbiology and Immunology, School of Medicine, & Institute of Microbiology and Immunology, Chung Shan Medical University, Taichung 402, Taiwan;dClinical Laboratory, Chung Shan Medical University Hospital, Taichung 402, Taiwan;eZoonoses Research Center & School of Veterinary Medicine, National Taiwan University, Taipei 106, Taiwan;fDepartment of Veterinary Medicine, College of Veterinary Medicine, National Chung-Hsing University, Taichung 402, Taiwan;gDepartment of Integrated Medicine, Show Chwan Memorial Hospital, Changhuan 500, Taiwan;hGraduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan;iComplementary and Integrative Medicine Center, E-DA Hospital, Kaohsiung, Taiwan |
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| Abstract: | Chronic alcohol consumption or alcohol abuse is the main cause of alcoholic steatohepatitis or further cirrhosis. This study was to exam if the antioxidant capacity and alcohol metabolism in livers of chronic alcohol-fed rats were improved by supplementing taurine (Tau). Rats were randomly divided into four groups with five times per week of treatment: 1) isocaloric solution; 2) 3 g alcohol/kg BW/day; 3) 3 g alcohol/kg BW/day + 1 g taurine (Tau)/kg BW/day; and 4) 3 g alcohol/kg BW/day + 2 g Tau/kg BW/day. A 6-week alcohol consumption resulted in lower (p < 0.05) body weight gain and self-antioxidant capacities, as well as increased (p < 0.05) liver size, serum/hepatic lipids, and AST and ALT values. However, alcohol-fed rats co-treated with Tau have decreased (p < 0.05) liver lipid levels via increasing fecal lipid output and cholesterol metabolism. Besides, co-treatment of Tau also enhanced (p < 0.05) self-antioxidant capacities and alcohol metabolism in livers via enhancing GSH contents, CAT, GSH-Px, ADH, and ALDH activities, but decreasing MDA contents. In a histological examination of rat liver, microvesicular steatosis and necrotic cells were observed in alcohol-fed rats without Tau while largely suppressed microvesicular steatosis and no necrotic cells were observed in alcohol-fed rat supplemented with Tau. Therefore, Tau could be an effective hepatoprotective agent against alcohol-induced damage via enhancing self-antioxidant capacity and alcohol metabolism. |
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| Keywords: | Abbreviations: ADH alcohol dehydrogenase ALDH aldehyde dehydrogenase ALT alanine aminotransferase AST aspartate aminotransferase CAT catalase CYP2E1 cytochrome P450 subfamily e polypepetide 1 GSH glutathione GSH-Px glutathione peroxidase MDA malondialdehyde Tau taurine TC total cholesterol TG total triglyceride |
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