| 2,4-二氯-6-乙基-5-氟嘧啶的合成方法研究 |
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| 引用本文： | 王相承,宫永利.2,4-二氯-6-乙基-5-氟嘧啶的合成方法研究[J].化学世界,2004,45(5):265-266,257. |
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| 作者姓名： | 王相承 宫永利 |
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| 作者单位： | 中国人民解放军防化指挥工程学院化工研究所,北京,102205;中国人民解放军防化指挥工程学院化工研究所,北京,102205 |
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| 摘 要： | 研究2,4-二氯-6-乙基-5-氟嘧啶的合成工艺。以2,4-二氯-5-氟嘧啶为原料,先与格氏试剂反应,再催化氧化得到2,4-二氯-6-乙基-5-氟嘧啶。研究了不同配比、反应时间等因素对转化率的影响,为实现工业化生产提供了理论基础。
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| 关 键 词： | 2 4-二氯-5-氟嘧啶 格氏试剂 4-二氟-6-乙基-5-氟嘧啶 |
| 文章编号： | 0367-6358(2004)05-0265-02 |
Preparation of 2,4-Dichloro-6-ethyl-5-fluoropyrimidine |
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| WANG Xiang-cheng,GONG Yong-li.Preparation of 2,4-Dichloro-6-ethyl-5-fluoropyrimidine[J].Chemical World,2004,45(5):265-266,257. |
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| Authors: | WANG Xiang-cheng GONG Yong-li |
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| Abstract: | A process for the preparation of 2,4-Dichloro-6-ethyl-5-fluoropyrimidine is reported. 2,4-Dichloro-5-fluoropyrimidine is used as the starting material. It first reacts with the Grinard reagent and then oxidizes catalytically to form 2,4-dichloro-6-ethyl-5-fluoropyrimidine. The influential factors such as the ratio of reagents and reaction time,are investigated. This provides work a base for future commercial production. |
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| Keywords: | 2 4-dichloro-5-fluoropyrimidine Grinard reagent 2 4-dichloro-6-ethyl-5-fluoropyrimidine |
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