药物载体淀粉微球的制备及表征

选用V(环己烷)∶V(三氯甲烷)=4∶1构成混合油相,淀粉水溶液为水相,m(Span 60)∶m(Tween 60)=3∶2复配为乳化剂,N,N′-亚甲基双丙烯酰胺为预交联剂,环氧氯丙烷为交联剂,采用反相乳液聚合方法制备了淀粉微球;用粒度分析仪、扫描电镜、红外光谱等对产物进行了表征。结果表明,淀粉微球平均粒径为14.7μm,83%分布在6~30μm,球形圆整,表面光滑致密,可作为良好的药物载体和吸附剂。通过单因素实验和正交设计实验考察了制备条件对微球理化性质的影响,推导出平均粒径与主要影响因素之间的多项回归方程,以期通过优化工艺条件实现对微球制备的预测和控制。

Preparation and Characterization of Starch Microspheres as Drug-carrier

Using cyclohexane and chloroform(V(cyclohexane)∶V(chloroform)=4∶1) as oil phase,starch solution as aqueous phase,and Span 80 and Tween 60(m(Span 60)∶m(Tween 60)=3∶2) as complex surfactant,starch microspheres were synthesized by inverse emulsion polymerization with N,N′-methylenebisacrylamide as precrosslinker and epichlorohydrin as crosslinking agent.The product was characterized by FTIR,SEM and granularity analyzer.The results show that the average particle size of the starch microspheres is about 14.7 μm and 83% of the microspheres is distributed in the range 6～30 μm.The microspheres are round,smooth and densified,which can be used as a kind of good drug-carrier or adsorbents.