Lipid composition of liver mitochondria and microsomes in hyperthyroid rats |
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Authors: | F M Ruggiero C Landriscina G V Gnoni E Quagliariello |
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Affiliation: | (1) Research Unit on Mitochondria and Energy Metabolism, C.N.R., Via G. Amendola 165/A, 70126 Bari, Italy;(2) Biochemistry Laboratory, Veterinary Faculty, University of Bari, Bari, Italy;(3) Centro di Studio sui Mitocondri, e Metabolismo Energetico, c/o Universitá di Bari, Via G. Amendola 165/A, 70126 Bari, Italy |
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Abstract: | Triiodothyronine-induced alteration of the lipid pattern in rat-liver mitochondria and microsomes has been investigated. In
mitochondria, a 25% total cholesterol decrease and a 14% phospholipid increase have been detected. In these hyperthyroid rat
liver organelles, a strong decrease in the total cholesterol/phospholipid molar ratio occurs. On the contrary, in microsomes
from the same animals, a decrease of about 23% has been measured for both total cholesterol and phospholipids; hence, in this
fraction, the total cholesterol/phospholipid molar ratio is unaffected by hyperthyroidism. The liver mitochondrial phospholipid
composition, unlike the microsomal composition, is altered significantly in hyperthyroid rats; a 7.4% phosphatidylcholine
decrease is accompanied by a similar additive percentage increase of both phosphatidylethanolamine and cardiolipin. In regard
to total phospholipid fatty acid composition in liver microsomes from hyperthyroid rats, no variation has been observed compared
with the control rats, whereas in mitochondria from the same animals, a meaningful linoleic acid decrease with a similar arachidonic
acid increase has been found. In addition to fatty acid alteration, the separated mitochondrial phospholipid classes also
exhibit some increase in stearic acid. Among phospholipids, cardiolipin changes the most of the esterified fatty acids in
hyperthyroid rat liver. In this compound, a strong increase in the percentage of both palmitic and stearic acid and a 32.4%
decrease of linoleic acid have been found. |
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