Abstract: | The authors studied changes in chemiluminescence and activity of three antioxidant enzymes in peripheral blood red cells in experimental diabetes mellitus induced in rats by alloxan injection. Intensification of red cell chemiluminescence reflected enhanced lipid peroxidation. High activity of catalase and superoxide dismutase activity was compensatory. A two-fold fall in glutathione reductase activity from the 7th day after alloxan injection demonstrates a decline in antioxidant defense in diabetes mellitus. |