Random amplified polymorphic DNA (RAPD) sequences as markers for canine genetic studies |
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Authors: | M Olivier MA Meehl G Lust |
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Affiliation: | Department of Internal Medicine I, University of Heidelberg, Luisenstrasse 5, D-69115, Heidelberg, Germany. |
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Abstract: | Our knowledge of the concentration of growth factors in growing bone is limited. In the present study, we examined the developmental changes in the concentrations of insulin-like growth factor I (IGF-I) and transforming growth factor beta (TGF-beta) in the rat femur between weanling and maturity. We show that during the rapid growth phase there is a continuous rise in bone matrix IGF-I and TGF-beta in all compartments of the femoral bone. The association between IGF-I and TGF-beta is not only temporal, but with few exceptions is also observed within the animals of each age class. These data support the hypothesis that IGF-I and TGF-beta play an important role in the growth-associated accumulation of bone mass. |
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