| 对甲苯磺酸催化7-羟基-4-甲基香豆素的无溶剂合成 |
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| 引用本文： | 秦省军,辛秀兰,徐宝财.对甲苯磺酸催化7-羟基-4-甲基香豆素的无溶剂合成[J].化工中间体,2007(12):8-10. |
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| 作者姓名： | 秦省军 辛秀兰 徐宝财 |
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| 作者单位： | 北京工商大学,化学与环境工程学院,北京,100037 |
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| 摘 要： | 以对甲苯磺酸为催化剂、乙酰乙酸乙酯和间苯二酚为原料通过Pechmann反应合成7-羟基-4-甲基香豆素。探讨了以对甲苯磺酸为催化剂时反应温度、催化剂用量、反应时间、原料比诸因素对产品收率的影响。实验表明：对甲苯磺酸是合成7-羟基-4-甲基香豆素的良好催化剂,在反应温度为125℃、反应时间为50min、n（间苯二酚）∶n（三乙）=1∶1.0、催化剂的用量为0.4g（间苯二酚为0.04mol）时,产品收率为65.5%。
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| 关 键 词： | 对甲苯磺酸 香豆素 无溶剂合成 |
| 文章编号： | 1006-253X（2007）12-008-3 |
| 收稿时间： | 2007-10-08 |
| 修稿时间： | 2007年10月8日 |
Solventless Synthesis of 7-Hydroxy-4-methyl Coumarin Catalysed by Para-toluenesulfonic Acid Catalyst |
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| Authors: | QIN Sheng-jun XIN Xiu-lan XU Bao-cai |
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| Affiliation: | QIN Sheng-jun, XIN Xiu-lan, XU Bao-cai (School of Chemical and Environmental Engineering, Beijing Technology and Business University, Beijing 100037, China) |
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| Abstract: | 7-Hydroxy-4-methyl coumarin was synthesized catalysed by para-toluenesulfonic acid from ethylacetoacetate and resorscinol under solventless condition. The optimum conditions of para-toluene- sulfonic acid were as follows： the molar ratio of ethylacetoacetate to resorscinol was 1：1, the quantity of catalyst was 0.4 gram（when resorscinol was 0.04mol）, the reaction temperature was 125℃, and the reaction time was 50min. The yield of 7-hydroxy-4-methyl coumarin could reach 65.5%.. |
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| Keywords: | para-toluenesulfonic acid coumarin solventless synthesis |
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