Ni-Ti-LDHs纳米片对阿司匹林的负载与缓释

采用插层法和剥离-重组法制备了阿司匹林-双金属氢氧化物复合物(A-LDHs)和阿司匹林-双金属氢氧化物纳米片复合物(A-LDHs-NS)。采用XRD、SEM、TG-DTG和FT-IR对复合物的形貌、载药性能和载药模型进行表征。测定了阿司匹林在不同pH环境中从A-LDHs和A-LDHs-NS上的释放性能。研究发现, 实验制备的LDHs和LDHs-NS均具有明显层状结构。LDHs-NS因具有较大的比表面积(187 m ²·g ^-1)能负载更多的阿司匹林。同时, LDHs-NS与阿司匹林之间有较强的相互作用, 载药量为1.178 mmol·g ^-1, 释放时间超过1440 min, 与对照组(20 min)相比, 表现出更优异的缓释性能, 且在pH为7.4的磷酸盐缓冲溶液中缓释性能比在pH为4.8中更强。本研究结果可以为二维材料在生物医药中的应用提供参考。

Aspirin on Ni-Ti-LDHs Nanosheets: Load and Sustained-release

Aspirin/layered double hydroxides composite(A-LDHs)and aspirin/layered double hydroxide-nanosheets composite(A-LDHs-NS)were prepared by intercalation and exfoliation-recombination,respectively.Their morphology,drug loading property and drug loading mode of the composites were characterized by XRD,SEM,TG-DTG,and FT-IR.The releasing performances of aspirin from A-LDHs and A-LDHs-NS in the phosphate buffer solutions with different pH conditions were investigated.The results show that the typical lamellar structures are hold in as-prepared LDHs and LDHs-NS.The larger specific surface area(187 m2·g–1)of LDHs-NS,the more aspirins are loaded on its surface,among which the max drug loading is 1.178 mmol·g–1.Its releasing process lasts for more than 1440 min,much longer than 20 min of the control materials,showing excellent sustained-releasing performance.This performance may because of the strong interaction between aspirin and LDHs-NS.Moreover,the sustained releasing performance is stronger at pH 7.4 than that at pH 4.8.All data from this study provides a reference for wider application of this kind of two-dimensional materials in biomedicine.