Characterization of Fe(III)-deferoxamine and Mn(II)-pectin as magnetic resonance imaging contrast agents |
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Authors: | Y Mino H Kitagaki M Sasaki K Ishii T Mori K Yamada O Nagasawa |
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Affiliation: | Department of Pharmacognosy, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan. |
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Abstract: | To find new contrast agents for magnetic resonance imaging (MRI), the spin-lattice relaxation time (T1)-reducing activities of metal complexes of EDTA, N-hydroxyethyethylenediamine-N,N',N'-triacetic acid (HEDTA), diethylenetriamine-N,N,N',N',N'-pentaacetic acid (DTPA), deferoxamine, mugineic acid, and pectin with Fe(III) or Mn(II) were investigated. Strong activity was found in Fe(III)-deferoxamine, Fe(III)-mugineic acid, or Mn(II)-pectin. In the actual MRI tomogram, Fe(III)-deferoxamine exhibited a contrast-enhancing effect comparable with that of Gd(III)-DTPA, and a much stronger effect was observed for Mn(II)-pectin. Fe(III)-deferoxamine and the Mn(II)-pectin appear to be candidates, respectively, as a new intravenous contrast agent and an oral gastrointestinal one. |
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