Glucose recognition capabilities of hydroxyethyl methacrylate‐based hydrogels containing poly(ethylene glycol) chains |
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| Authors: | Hatice Bodugoz Olgun Güven Nicholas A Peppas |
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| Affiliation: | 1. Laboratories of Biomaterials, Drug Delivery and Molecular Recognition, Department of Chemical and Biomedical Engineering and Division of Pharmaceuticals, University of Texas at Austin, Austin, Texas 78712;2. Department of Chemistry, Hacettepe University, 06532, Beytepe Ankara, Turkey |
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| Abstract: | A configurational biomimetic imprinting technique was used to prepare recognition sites for glucose in copolymers of 2‐hydroxyethyl methacrylate (HEMA) and methacrylic acid (MAA) prepared with crosslinking agents containing poly(ethylene glycol) (PEG). We report on the structure, diffusive, and recognition characteristics of these gels, the effect of the type and ratio of crosslinking agent, as well as the template/comonomer ratios on glucose binding ability. The highest equilibrium glucose binding was found as 2.67 mg/g dry polymer when PEG monomethacrylate (PEGMMA) was used in combination with tetra ethylene glycol dimethacrylate (TEGDMA) (50%) as a crosslinking agent. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 103: 432–441, 2007 |
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| Keywords: | configurational biomimetic imprinting 2‐hydroxy ethyl methacrylate (HEMA) methacrylic acid (MAA) poly (ethylene glycol) (PEG) glucose |
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